![]() Fifty-one of the patients were included in the primary analysis, and 36 of these received complete titration of prazosin and 8 additional weeks of prazosin treatment after titration.21 A separate analysis was conducted for the 36 subjects who completed the study. These affect less than 1% of people that take the drug and include: If a person takes prazosin and experiences any severe side effects, including fainting, weakness, tachycardia, impotence, or orthostatic hypotension, they should consider alternative treatments. Patient's medication list upon intake to the psychiatry clinic. The most promising of the three is a large (326 estimated participants), multicenter, randomized, double-blind, placebo-controlled stud圓2 that is being overseen by Raskind and has an estimated completion date of 2012. Case reports18,19,28 have further documented extreme sedation, alterations in normal behavior, and a feeling described by one patient as blurred awareness of the line between dreaming and reality. – The relatively low level of suicidal ideation in this study may have made it difficult to find an effect of prazosin.2008 21(4):417-420. – Sleep problems, such as nightmares and insomnia, improved within this treatment study regardless of whether they received prazosin or placebo – Most people with PTSD in the study also had a treatable mood disorder Since participants in this study had mild to moderate suicidal ideation, the effect of prazosin for those with more severe suicide risk is not yet known. Many individuals stopped treatment before the end of the eight weeks. There were no suicide attempts or deaths. Overall, two patients (one from each group) were hospitalized for worsening symptoms or suicidal ideation. Contrary to what the researchers expected, patients in the placebo group experienced significantly greater improvements in the nighttime severity of nightmares and insomnia than those in the group that received prazosin. Patients in each treatment group experienced improvements in all outcomes (severity of suicidal ideation, nightmares, depressed mood, PTSD, and insomnia) over the eight weeks of the study. Finally, during each weekly check-in, participants were reassessed to monitor both daytime and nighttime changes in the severity of suicidal ideation, nightmares, depressed mood, PTSD, and insomnia. Each group received doses of either prazosin or the placebo once nightly at bedtime for eight weeks. ![]() The study was double-blind, meaning that neither the researchers, nor the participants, knew who was receiving prazosin or placebo until the study was completed. One group received nighttime doses of prazosin, and the other group received a placebo (a pill appearing identical to the prazosin but without the ingredients of the drug). Participants were then randomly assigned to one of two treatment groups. Within the four weeks prior to their participation in the study, all patients were administered selective serotonin reuptake inhibitors (SSRIs medications commonly used to treat depression) for the treatment of their depressive mood disorders, or an approved medicine for their bipolar disorder. Researchers observed that most participants had a mood disorder such as major depression or bipolar disorder along with PTSD. Participants were assessed for other psychiatric disorders as well as severity of nightmares, depressed mood, PTSD, insomnia, and suicidal ideation. William Vaughn McCall and his team at the Medical College of Georgia recruited twenty adults who were receiving outpatient treatment for PTSD. William Vaughn McCall proposed that prazosin, a medication used to treat nightmares, would also help to reduce suicidal ideation in patients with PTSD.Ĭan Medication for the Treatment of Nightmares Also Reduce Suicidal Ideation in People with Post-Traumatic Stress Disorder?ĭr. Sleep problems such as nightmares and insomnia are often experienced by people with Post-Traumatic Stress Disorder (PTSD), and research has suggested an association between sleep problems and suicide.ĭr.
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